The skin is the only organ which undergoes cellular renewal during a person’s entire lifetime. As a consequence, epidermis cells always need energy and nutrients to remain active and functional. It is clamed that all cells are mechano-sensitive. Mechanobiology refers to a process whereby mechanical stimulation (vibration, torsion and stretching) is applied to biological tissues. The effectiveness of many of the mechanical therapies already in clinical use shows how important physical forces can be in physiological control. Mechanobiology is an emerging field of science at the interface of biology and engineering that focuses on how physical forces and changes in the mechanical properties of cells and tissues contribute to development, cell differentiation, physiology, and disease. Stretch-activated ion channels, caveolae, integrins, cadherins, growth factor receptors, myosin motors, cytoskeletal filaments, nuclei, extracellular matrix, and numerous other molecular structures and signalling molecules have been shown to contribute to cellular mechanotransduction. That’s why, FRAME® have created a specific collection of devices intended to safely meet these specific needs at home.